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How does myPGx work?

How does myPGx work?

09.JAN.2023

Written by Anna Sanniti

Reviewed by Wendi Gill, CGC

The myPGx genetic test by LetsGetChecked identifies potential drug-gene interactions for 100+ medications across cardiovascular, pain medication, and behavioral health categories. This single test enables your providers to better understand how your genes affect how you react to drugs. Anyone curious about their genetics can take a myPGx test to learn more about their body. In this article, we will discuss:

  • The basics of the testing procedure

  • What happens to the test sample

The basics of the testing procedure

You will receive a myPGx kit through the mail to your home address. The kit will contain all of the instructions you need to carry out the test, including a special kit to collect your saliva sample. The kit will contain everything you need to collect your saliva sample and return it to the laboratory. If you have received a stem cell, liver, or bone marrow transplant in the past, this test is not suitable for you. This is because the test may sequence some DNA from your donor, and the results will not be accurate. It is recommended that you wait until 4 months after chemotherapy and 6 weeks after a blood transfusion before collecting your sample.

What happens to my sample?

Once you have sent off your sample and it has been received in the laboratory, your DNA will be extracted from your saliva sample and sequenced. The myPGx test will only look for genetic variants found in 24 genes within the gene panel. These genes are listed below:

  • ABCG2

  • ADRA2A

  • BDNF

  • CACNA1C

  • COMT

  • CYP1A2

  • CYP2B6

  • CYP2C19

  • CYP2C8

  • CYP2C9

  • CYP2D6

  • CYP3A4

  • CYP3A5

  • CYP4F2

  • Prothrombin (F2)

  • Factor V

  • GRIK4

  • HTR2A

  • HTR2C

  • MTHFR

  • OPRM1

  • SLCO1B1

  • VKORC1

  • UGT2B15

Once we receive your test kit, our processing time is approximately 2 weeks. Once your results are ready, our healthcare team will reach out to you to make an appointment to discuss the test, its meaning, and how to proceed with your provider. You will then receive a detailed report containing your results. As your DNA sequence does not change, these results can be used to inform relevant treatments for life. LetsGetChecked also has a dedicated staff of Pharmacists with specialty pharmacogenomics experience available to provide consultations to you and your provider.

Let’s recap

  • The myPGxgenetic test will look for genetic variants in 24 genes linked to potential drug-gene interactions, using DNA extracted from a saliva sample.

  • You will receive your sample collection kit through the mail. The kit will contain everything you need to collect and return your sample to the laboratory.

  • You will receive a report with your results within 2 weeks, which you should discuss with your health care provider.

We encourage you to share all results with your healthcare providers. They can provide guidance based on your individual situation. Let them know if you have any concerns or questions.